Use the following zoom and pan buttons to control the image that follows them
Tab through the images or use the previous or next buttons to navigate each product image
or
Highlights
Summary
DERMA E's Anti-Wrinkle Renewal Cream delivers targeted wrinkle correction with weightless hydration. Derm-recommended Retinol works synergistically with Bakuchiol to refine texture and visibly soften fine lines, while Vitamin E and Panthenol support the skin barrier and boost skin’s resilience.
Benefits
- Helps visibly reduce the look of fine lines and wrinkles
- Nourishes and smooths skin for a healthier-looking complexion
- Soothes and supports skin barrier health
- Provides lightweight, all-day hydration
Key Ingredients
- RETINOL: #1 dermatologist-recommended ingredient to reduce the appearance of fine lines and wrinkles†
- PANTHENOL (PRO-VITAMIN B5): a moisture-binding ingredient that strengthens the skin barrier and improves smoothness
- BAKUCHIOL: a gentle, plant-based retinol alternative that helps smooth texture and reduces the look of lines
- VITAMIN E: a nourishing antioxidant that helps protect skin from dryness and leaves skin soft and supple
- ALLANTOIN: a soothing skin protectant that helps keep skin smooth and calm
- †Based on an internal survey of 35 dermatologists.
Research Results
- 97% saw reduced fine lines and wrinkles †
- † Results based on single use independent clinical study after 8 weeks using the Anti-Wrinkle Collection (Cleanser, Oil, Night Treatment, Smoothing Eye Cream, and Renewal Cream)
Item 2556321
Apply onto clean face and neck. Use in the evening.
Tip: Be sure to apply ample SPF in the morning to keep skin protected!
Purified Water, Carthamus Tinctorius (Safflower) Seed Oil, Stearic Acid (Vegetable Derived), Glycerin (Vegetable Derived), Glyceryl Stearate SE, Cetyl Alcohol (Plant Derived), Microcrystalline Cellulose (Plant Derived), Cellulose Gum (Plant Derived), Persea Gratissima (Avocado) Oil, Sesamum Indicum (Sesame) Seed Oil, Helianthus Annuus (Sunflower) Seed Oil, Bakuchiol, Retinol, Panthenol (Provitamin B5), Tocopheryl Acetate (Vitamin E), Allantoin, Phenoxyethanol, Ethylhexylglycerin, Natural Fragrance Oils.
Similar items for you
12 items
Use previous and next buttons to navigate the slides of the Similar items for you Product Carousel
We think you'll like
12 items
Use previous and next buttons to navigate the slides of the We think you'll like Product Carousel
Sponsored products
12 items
Use previous and next buttons to navigate the slides of the Sponsored products Product Carousel
Reviews
Review Snapshot
by PowerReviews
Ratings Distribution
Best For
Describe Yourself
Skin Type
Most Helpful Positive Review
If you have tough skin: 10/10!!!
Im 24, 1/2 Asian, 1/2 white, I have very combination to dry skin, and pretty tolerant skin with Minimal breakouts. So take my review with a grab of salt if you have sensitive or difficult, acne prone skin. I am IN LOVE with this product. I love that it is truly effective on my face. Im pretty inco...
Most Helpful Critical Review
Formula is a little greasy
I found this formula very greasy for my face and started to breakout with acne after using. I don't typically have acne, maybe the occasional pimple at worst. However, I now use it as a hand cream and it feels luxurious when used as a hand cream. I bought this cream as an alternative to R&F Redefine...
271 results
So far I like it
Was using Drunk Elephant Protini for years and wanted to try something less pricey and more basic so settled on this. So far I like it - you don't need much - but it does have a strange smell to it that I had to adjust to; not a deal braker but just a heads up. Not like the thirst-quenching and lightness of Protini, but this definitely seems to firm the skin more, and seems to last a bit longer. It has more of a utilitarian quality to it and for that I think people will see it as a good alternative to Cerave and the usual - this company seems to be small and I like that, too.
nice product
been using this product for years, I like how smoothly it goes on, and the price when on sale.
Perfect balance of moisture without feeling greasy
Reviewed at

I've been using this cream for about 10 years. Occasionally, I will try another one by DermaE, but I always come back to this one It's; soothing, moisturizing and never feels greasy. Added bonus, it doesn't have a strong smell. I use this both night and day for soft, skin that never feeela greasy.
Amazing cream
Instantly wrinkles are gone! This stuff is incredible. You can feel a difference on your face the first day. Its not too heavy or light. Definitely recommend, I got it on Black Friday and next year Ill get more
Perfect daily moisturizer
Reviewed at

I use this all year! It goes on smoothly and easily. It's light weight, but keeps my skin feeling good whether it's humid or bone dry. I really like that you don't feel it or notice oily spots. I wish I could get a 5 gallon bucket of this stuff.


Questions
Q&A
Showing 6 out of 6 Questions
- Q
Does this have any peptides in it?
- Asked by Lisa
- Official Answer By DERMA E - Brand EngageIf you're looking for peptides, we recommend our Advanced Peptides and Flora-Collagen line!Was this answer helpful to you
- Q
Is this used as a moisturizer, or should I still follow it up with my normal daily moisturizer?
- Asked by Cris
- Official Answer By DERMA E - Brand EngageThis is to be used as a moisturizer.Was this answer helpful to you
- Q
What is the retinol percentage?
- Asked by C
- Official Answer By DERMA E - Brand EngageThank you for your interest in our ingredients. While we don't disclose the exact percentage of retinol this formula, I can tell you that it is always formulated at the concentration recommended for maximum results without irritation. Beyond that, it’s good to know that the percentage of an ingredient in a formula is just one part of the story. When designing each formula, DERMA E carefully considers the product’s effectiveness, natural content, pH balance, gentleness and safety.Was this answer helpful to you
- Q
Does this product come in a box?
- Asked by Jam
- Official Answer By DERMA E - Brand EngageThis product is not packaged in a box.Was this answer helpful to you
- Q
I'm a little confused, the picture of the container doesn't have the word retinol in it nor did I see any forms of retinol in the ingredient listing. Why is the title of this product page have the word retinol in it?
- Asked by michelle
- Official Answer By DERMA E - Brand EngageHere are the ingredients, including retinol (the 7th to last ingredient): "Purified Water, Carthamus Tinctorius (Safflower) Seed Oil, Stearic Acid (Vegetable Derived), Glycerin (Vegetable Derived), Glyceryl Stearate SE, Cetyl Alcohol (Plant Derived), Microcrystalline Cellulose (Plant Derived), Cellulose Gum (Plant Derived), Persea Gratissima (Avocado) Oil, Sesamum Indicum (Sesame) Seed Oil, Helianthus Annuus (Sunflower) Seed Oil, Bakuchiol, Retinol, Panthenol (Provitamin B5), Tocopheryl Acetate (Vitamin E), Allantoin, Phenoxyethanol, Ethylhexylglycerin, Natural Fragrance Oils."Was this answer helpful to you
- Q
Is this like other retinol products where you have to use just a little bit every other day until your skin adjusts? Most products are strong and cause some initial irritation, redness, or breakouts, but this seems like it might be more gentle?
- Asked by gran
- Official Answer By DERMA E - Brand EngageOur retinol products are gentle but with all retinol use it is best to slowly introduce to your skin.Was this answer helpful to you