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Summary
A new-generation longevity face serum for all skin types formulated with Mitopure® to intercept visible biological aging signs before they appear. *Visible biological age defined as signs of aging such as firmness, suppleness, radiance, fine lines, smoothness, etc.
Benefits
- Formulated with Mitopure®, 98.5% pure and micronized form of Urolithin-A, a postbiotic widely recognized in the longevity field*.
- Mitopure® is combined with the new proprietary and unique Intercept compound. This complex fuses LHA, Matrixyl™, Niacinamide, and Rose Pro-Xylane with Taurine to intercept specific visible skin markers according to your visible biological age - the only age you can reverse.
- *Absolue Longevity MD provides a topical cosmetic way to combat visible signs of aging. Does not function like Mitopure oral supplement.
Key Ingredients
- Mitopure®: A postbiotic widely recognized in the longevity field
- Matrixyl™: A powerful peptide complex known to help reduce the appearance of wrinkles
- LHA: Known to help promote surface cell turnover & fine lines
Research Results
- Clinically measured visible and invisible results
- Visible:
- 11 Visible Biological Aging Signs Targeted*
- Up to -58% Nasolabial Folds**
- Up to -57% Crows Feet**
- Up to +45% Firmness**
- Up to -33% Forehead Wrinkles**
- Invisible: +3 million new surface cells per day***
- *Clinical study measuring improvement on forehead wrinkles, crow’s feet wrinkles, nasolabial folds, lower face ptosis, underneath eye wrinkles, corner of the lip wrinkles, interocular wrinkles, radiance, firmness, dropping eyelid and tear through after 3 months
- **Clinical testing after 12 weeks showed results up to 33% and average results of -17% forehead wrinkles, results up to +45% and average results of +30% firmness, results up to -57% and average results of -35% crow’s feet, results up to -58% and average results of -30% nasolabial folds.
- ***Clinical study based on exfoliation over 3 weeks vs. untreated skin
Item 2652989
- Apply 1 pump
- Smooth over neck & face
- Smooth in a kneading motion
Aqua / Water / Eau, Glycerin, Alcohol Denat., Octyldodecanol, Niacinamide, Dimethicone, C14-22 Alcohols, Hydroxypropyl Tetrahydropyrantriol, Paraffinum Liquidum / Mineral Oil / Huile Minerale, Urolithin A, Limnanthes Alba Seed Oil / Meadowfoam Seed Oil, Isopropyl Lauroyl Sarcosinate, Rosa Damascena Flower Water, Carbomer, Saccharomyces Ferment Filtrate, Sodium Acetylated Hyaluronate, Sodium Hyaluronate, Sodium Lactate, Sodium Phosphate, Arginine, Palmitoyl Tetrapeptide-7, Palmitoyl Tripeptide-1, Adenosine, Poloxamer 338, Ammonium Polyacryloyldimethyl Taurate, Disodium Phosphate, Propanediol, Propylene Glycol, Hydroxyethylcellulose, Capryloyl Salicylic Acid, Citric Acid, Taurine, Trisodium Ethylenediamine Disuccinate, Maltodextrin, Polysorbate 20, Polysorbate 60, Butylene Glycol, C12-20 Alkyl Glucoside, Salicylic Acid, Phenoxyethanol, Caramel, Parfum / Fragrance (F.I.L. N70087833/1).
This brand is excluded from most Ulta Beauty coupons.
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Reviews
Review Snapshot
by PowerReviews
Ratings Distribution
Most Helpful Positive Review
Aging like fine wine!
[I received this product in exchange for my honest review] Okay… this is one of those products where the science actually made me pause for a second. As a nurse and aesthetician in my late 30s, I'm very much in that "intercept not chase" phase when it comes to aging. I don't want to wait until every...
Most Helpful Critical Review
Luxurious feeling serum, heavily fragranced
[I received this product in exchange for my honest review] The Lancôme Longevity MD Intercept Serum is a great addition to your skincare ritual, and I've been excited to try it as a 30-something who is starting to notice some changes in the look and feel of my skin. I've been using this for around...
93 results
Longevity at its best
I've been using this product daily now for about a month!!!! I'm loving how my skins looking it's so glowing. My makeup goes on so smooth and I feel hydrated all day! I'll definitely continue using it! The texture of my skin feels so smooth currently! It's easy to get the product out of the jar!

Love it
[I received this product in exchange for my honest review] I really love lancome products because they work. I have only been using this for a few weeks and I can already see that my skin have a healthier, fresher look to it. It has put a little more pep into my aging tired skin for sure. I really cant wait to see the results with continued usage. The packaging pretty and has some heft to it. Its a tad bit hard to read the word on it it the light is hitting it. With one pump the nozzle pits out a generous amount of product. The serum has a very light ,pretty scent that lingers after dry down. It absorbs into the skin quickly leaving it feeling silky smooth after application. Im really loving this serum overall.
Improvement in skin quickly
I have tried countless serums and this is my favorite so far. I usually don't find products I love to where I look for others to try. This serum is the perfect texture and has been amazing before applying the matching face cream. I plan to stick with this serum and look forward to the continued improvement. I turn 40 in 2 months and take my skincare routine seriously. My skin overall looks and feels much smoother and the product has worked well with my sensitive skin. [I received this product in exchange for my honest review]
Love it
[I received this product in exchange for my honest review] I love Lancome and I love this product. The Longevity MD Intercept Serum really helps tackle the beginning signs of aging. It helped to improve my fine lines around my eyes and generally lifted my face.

Liking it so far
I received this product for free in exchange for an honest review and I've actually been enjoying it so far. The serum feels lightweight, absorbs nicely and layers well with the rest of my skincare without feeling greasy or heavy. My skin feels smoother and more hydrated after using it consistently. The packaging feels pretty luxe too.